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Vision
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PUBLICATIONSSubtle metabolic and liver gene transcriptional changes underlie
diet-induced fatty liver susceptibility in insulin resistant mice A.A.
Toye, M.E. Dumas, C. Blancher, A.R. Rothwell, J.F. Fearnside, S.P. Wilder,
M.T. Bihoreau, O. Cloarec, I. Azzouzi, S. Young, R.H. Barton, E. Holmes, M.I.
McCarthy, R. Tatoud, J.K. Nicholson, J. Scott, D. Gauguier Diabetologia (in press) Statistical tools for synthesizing lists of differentially
expressed features in related experiments. Blangiardo M, Richardson S. Genome Biol. (2007) 8, R54 A top-down systems biology view of microbiome-mammalian metabolic
interactions in a mouse model François-Pierre J. Martin, Marc-Emmanuel Dumas,
Yulan Wang, Cristina Legido-Quigley, Ivan K. S. Yap, Huiru Tang, Séverine
Zirah, Gerard M. Murphy, Olivier Cloarec, John C. Lindon, Norbert Sprenger,
Laurent B. Fay, Sunil Kochhar, Elaine Holmes, and Jeremy K. Nicholson Molecular Systems Biology (2007, in press) Tail posterior probability for
inference in pairwise and multiclass gene expression data N.
Bochkina, Biometrics (2007, in press) Mass spectrometry of
glycoprotein glycans.Dell A, Chalabi S, Hitchen PG, Jang-Lee
J, Ledger V, North SJ, Pang P-C, Parry S, Sutton-Smith M, Tissot B, Morris
HR, Panico M, Haslam SM In: Comprehensive
Glycoscience. Elsevier (2007 in
press) Integrated mass spectrometric
strategy for characterising the glycans from glycosphingolipids and
glycoproteins : direct identification of sialyl Lex in mouse.Parry
S, Ledger V, Tissot B, Haslam SM, Scott J, Morris HR, Dell A.
Dumas ME, Wilder SP, Bihoreau MT, Barton RH,
Fearnside JF, Argoud K, D'Amato L, Wallis RH, Blancher C, Keun HC, Baunsgaard
D, Scott J, Sidelmann UG, Nicholson JK, Gauguier D. Nat Genet. (2007) 39, 666-672 Virtual Chromatographic Resolution Enhancement in Cryoflow LC-NMR
Experiments via Statistical Total Correlation Spectroscopy. Cloarec O, Campbell A, Tseng LH, Braumann U,
Spraul M, Scarfe G, Weaver R, Nicholson JK. Anal
Chem. (2007) 79, 3304-3311 Detection of Urinary Drug Metabolite (Xenometabolome) Signatures
in Molecular Epidemiology Studies via Statistical Total Correlation (NMR)
Spectroscopy.Holmes E, Loo RL, Cloarec O, Coen M, Tang H,
Maibaum E, Bruce S, Chan Q, Elliott P, Stamler J, Wilson ID, Lindon JC,
Nicholson JK. Anal Chem. 2007
79, 2629-2640 N-Glycosylation of the MUC1
mucin in epithelial cells and secretions. Parry
S, Hanisch FG, Leir SH, Sutton-Smith M, Morris HR, Dell A, Harris A. Glycomics investigation into
insulin action. Parry
S, Hadaschik D, Blancher C, Kumaran MK, Bochkina N, Morris HR, Richardson S,
Aitman TJ, Gauguier D, Siddle K, Scott J, Dell A. Susceptibility of human metabolic phenotypes to dietary
modulation.Stella C, Beckwith-Hall B, Cloarec O, Holmes E,
Lindon JC, Powell J, van der Ouderaa F, Bingham S, Cross AJ, Nicholson JK. J Proteome Res. (2006) 5, 2780-8. Statistically integrated metabonomic-proteomic studies on a human
prostate cancer xenograft model in mice.Rantalainen M, Cloarec
O, Beckonert O, Wilson ID, Jackson D, Tonge R, Rowlinson R, Rayner S, Nickson
J, Wilkinson RW, Mills JD, Trygg J, Nicholson JK, Holmes E. J Proteome Res. (2006) 5, 2642-55. Transgenomic metabolic interactions in a mouse disease model:
interactions of Trichinella spiralis infection with dietary Lactobacillus
paracasei supplementation. Martin FP, Verdu EF, Wang Y, Dumas ME, Yap IK,
Cloarec O, Bergonzelli GE, Corthesy-Theulaz I, Kochhar S, Holmes E, Lindon
JC, Collins SM, Nicholson JK. Related Articles, Links J Proteome Res. (2006) 5, 2185-93. Metabolic profiling reveals a contribution of gut microbiota to
fatty liver phenotype in insulin-resistant mice. Dumas ME, Barton RH, Toye A, Cloarec O, Blancher
C, Rothwell A, Fearnside J, Tatoud R, Blanc V, Lindon JC, Mitchell SC, Holmes
E, McCarthy MI, Scott J, Gauguier D, Nicholson JK. Proc Natl Acad Sci U S A. (2006) 103, 12511-6 Statistical search space reduction and two-dimensional data
display approaches for UPLC-MS in biomarker discovery and pathway analysis. Crockford DJ, Lindon JC, Cloarec O, Plumb RS,
Bruce SJ, Zirah S, Rainville P, Stumpf CL, Johnson K, Holmes E, Nicholson JK. Anal Chem. (2006) 78, 4398-408. Probing latent biomarker signatures and in vivo pathway activity
in experimental disease states via statistical total correlation spectroscopy
(STOCSY) of biofluids: application to HgCl2 toxicity. Holmes E, Cloarec O,
Nicholson JK. J Proteome Res. (2006) 5, 1313-20. Pharmaco-metabonomic phenotyping and personalized drug treatment. Clayton TA, Lindon JC, Cloarec O, Antti H,
Charuel C, Hanton G, Provost JP, Le Net JL, Baker D, Walley RJ, Everett JR,
Nicholson JK. Nature. (2006) 440, 1073-7. Scaling and normalization effects in NMR spectroscopic
metabonomic data sets. Craig A, Cloarec O, Holmes E, Nicholson JK,
Lindon JC. Anal Chem. (2006) 78, 2262-7. Mucin glycosylation and
sulphation in airway epithelial cells is not influenced by cystic fibrosis transmembrane
conductance regulator expression. Leir
SH, Parry S, Palmai-Pallag T, Evans J, Morris HR, Dell A, Harris A. Statistical total correlation spectroscopy: an exploratory
approach for latent biomarker identification from metabolic 1H NMR data sets. Cloarec O, Dumas ME, Craig A, Barton RH, Trygg J,
Hudson J, Blancher C, Gauguier D, Lindon JC, Holmes E, Nicholson J. Anal Chem. (2005) 77, 1282-9. Evaluation of the orthogonal projection on latent structure model
limitations caused by chemical shift variability and improved visualization
of biomarker changes in 1H NMR spectroscopic metabonomic studies. Cloarec O, Dumas ME, Trygg J, Craig A, Barton RH,
Lindon JC, Nicholson JK, Holmes E. Anal Chem. (2005) 77, 517-26. Exercise in rats does not alter hypothalamic AMP-activated
protein kinase activity Andersson U, Treebak JT, Nielsen JN, Smith KL,
Abbott CR, Small CJ, Carling D, Richter EA. Biochem Biophys Res Commun. (2005) 329, 719-25. Metabonomic investigations in mice infected with Schistosoma
mansoni: an approach for biomarker identification. Wang Y, Holmes E, Nicholson
JK, Cloarec O, Chollet J, Tanner M, Singer BH, Utzinger J. Proc Natl Acad Sci U S A. (2004) 101, 12676-81 AMP-activated protein kinase plays a role in the control of food
intake. Andersson U, Filipsson K, Abbott CR, Woods A,
Smith K, Bloom SR, Carling D, Small CJ. J Biol Chem. (2004) 279, 12005-8. updated 29May07 |
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© 2003 Imperial College Genetics and
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